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Covid-19 Vaccine

FROM THE ARCHIVES

As the world gears up for the fastest-ever developed vaccine, several drug companies have taken different routes to manufacture the antidote to the pandemic that has held the world hostage since March of this year.

According to the Johns Hopkins Coronavirus Resource Center, at least 1.3 million people have died as a result of and at least 59 million people have been infected with COVID-19 worldwide.

With the global economy at stake, millions working from home and, according to UNICEF, 463 million children around the world unable to access remote learning, the need for a vaccine is urgent.

A government-appointed panel of experts has approved a coronavirus vaccine developed by AstraZeneca and Oxford University for emergency use and will send its recommendations to the country’s drugs regulator, the Drugs Controller General of India
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This duo spent more than a decade cracking a complex viral puzzle—and their skills were needed once more. Their years of sleuthing and innovating ultimately contributed a microscopic but critical piece to the most promising candidates for COVID-19 vaccines. Two already authorized in the U.S. use their discovery, as do
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The World Health Organization has listed Pfizer-BioNTech’s COVID-19 vaccine for emergency use, a critical step that the United Nations health agency said aims to make the vaccine more readily available in developing nations.
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In what has become a familiar pattern, the COVID-19 vaccine landscape has changed overnight, simultaneously raising hopes that more people may soon get vaccinated and triggering confusion. “It’s crazy,” says immunologist John Moore, a vaccine researcher at Weill Cornell Medicine. “Every morning, it’s just, ‘What’s going on?’"
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A vaccine developed by China National Pharmaceutical Group (Sinopharm) has been found to be 79.34 per cent effective against Covid-19, according to an interim analysis, the company said.
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Our fundamental comprehension of immune responses to the coronavirus has grown significantly, but more questions—like the longevity of immunity—are still to be answered, especially amid concerns that mutations may help SARS-CoV-2 evade our immunological defenses.
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Like the Pfizer vaccine, the Moderna vaccine primes the immune system to attack the coronavirus that causes COVID-19 by delivering a snippet of the virus’s genetic code. That code — known as messenger RNA, or mRNA — instructs the body to build copies of the spike protein that studs the
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Shanghai Fosun Pharmaceutical Group Co Ltd on Wednesday said it will buy at least 100 million doses of a COVID-19 vaccine from Germany’s BioNTech SE for use in mainland China next year, if the vaccine receives approval.
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As more Covid-19 vaccines approach the finish line of regulatory approvals, the next challenge will be to produce and deliver hundreds of millions of doses as quickly as possible.
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"Higher income countries like the U.S. and the U.K. are putting themselves at the front of the line — that's obviously what's happening," Philip Clarke, a professor of health economics at the University of Oxford, said. "The clear failure here is not having stronger international institutions and stronger funding to
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Residents of two long-term care homes in Quebec will be the first to receive the Pfizer-BioNTech vaccine in that province. Francine Dupuis of the Montreal regional health agency says health care workers have been ready to administer the doses at Maimonides Geriatric Centre since Friday.
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Analysis of contracts countries are signing with vaccine makers for advance booking of candidates shows that the deals are still fluid, changing in a matter of days with some companies gaining and some losing orders given that most candidates are still in trial stage.
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Singapore has approved Pfizer-BioNTech's novel coronavirus vaccine and expects delivery of the first shots by the end of December, Prime Minister Lee Hsien Loong said on Monday. The city-state of 5.7 million people expects to have enough vaccines for everyone by the third quarter of 2021 and will make it
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Bahrain said Sunday it approved the use of a Chinese coronavirus vaccine, following its earlier approval of a vaccine made by Pfizer and its German partner BioNTech.
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Hospital systems nationwide should expect the first shipments of Pfizer's Covid-19 vaccine to arrive Monday, Gen. Gustave Perna, chief operating officer of Operation Warp Speed, said during a media briefing Saturday.
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The United States became the third highly developed Western country — after Britain and Canada — to approve the vaccine. But the three countries have very different health care systems. And they face different challenges in the race to get the vaccine to millions of people.
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The Hong Kong government weighed scientific, logistical, business and even political factors before choosing the manufacturers to supply millions of Covid-19 vaccine shots to the city’s residents, according to health experts and an insider close to the selection process.
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As the race to develop a COVID-19 vaccine concludes, a new one begins: the race to ensure that enough people are vaccinated to end the pandemic.
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Pfizer Inc. is packing boxes with thousands of its Covid-19 vaccines for shipment around the U.S., as hospitals gear up to give shots while also confronting the surging pandemic. Trucks carrying the fragile cargo at minus-94 degrees Fahrenheit will start rolling out of Pfizer plants in Michigan and Wisconsin on
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Africa Centers for Disease Control and Prevention Director John Nkengasong warned “it will be extremely terrible to see” wealthy nations obtaining vaccines and African countries missing out, as he called on for an extraordinary United Nations session to discuss this “moral issue” and avoid a “North-South distrust in respect to
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The scientists and the World Health Organisation (WHO) tell us the Covid-19 vaccines have been produced in an unprecedented spirit of worldwide co-operation. Scientists across many disciplines have shared information and these vaccines have arrived long before it would have been thought possible a year ago.
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The Food and Drug Administration has authorized the use of a COVID-19 vaccine developed by Pfizer and BioNTech, a landmark moment in the fight to suppress a virus that has killed nearly 300,000 people in the United States and sickened tens of millions around the world.
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Hong Kong has secured 15 million shots of Covid-19 vaccines manufactured in China and Europe, with the first million expected to be available next month for high-risk groups under a free, voluntary vaccination scheme for the city’s population of 7.5 million residents.
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France's Sanofi and Britain's GSK said Friday their Covid-19 vaccines will not be ready until the end of 2021, after interim results showed a low immune response in older adults. The announcement is a huge setback in efforts to fight the pandemic, which emerged in China last December and has
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The world is watching as the UK becomes the first test case of our collective ability to manufacture, ship, and deliver an entirely new class of vaccines, on a scale and speed that no previous vaccination drive in history has ever approached.
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Pharmaceutical and vaccine production involves complex coordination, involving product development, manufacturing, packaging, storage, distribution, and regulatory review, and each stage can cause unexpected delays.
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Development of a COVID-19 vaccine in Australia was abandoned Friday, December 11, after clinical trials produced a false positive HIV result among subjects involved in early-stage testing.
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Documents released by US regulators on Tuesday confirmed that Pfizer and BioNTech’s Covid-19 vaccine was strongly protective against the disease – offering the world’s first detailed look at the evidence behind the shots.
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Many Asian countries have signed agreements with vaccine makers for supply. India has secured 600 million doses, mostly from AstraZeneca, according to data from Airfinity, a science information and analytics company. China, Japan, Indonesia, South Korea and Thailand all have deals for millions of doses from the European company.
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Three vaccine companies have applied for early approval for emergency use in India: Serum Institute of India, which has been licensed to manufacture the AstraZeneca vaccine, Pfizer Inc and Indian manufacturer Bharat Biotech. “Some of them may get licensed in the next few weeks,” federal Health Secretary Rajesh Bhushan said.
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The Covid-19 vaccine being developed by the University of Oxford and AstraZeneca appears to have moderate efficacy in preventing symptomatic illness, and may significantly reduce hospitalization from the disease, data from four clinical trials of the vaccine reveal.
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A recent study has created a novel test using an ultrasensitive paper-based electrochemical sensor that can rapidly detect the presence of the virus in 5 minutes or less.
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An experimental coronavirus vaccine developed by China National Pharmaceutical Group (Sinopharm) has 86% efficacy, the health ministry of the United Arab Emirates said on Wednesday, citing an interim analysis of late-stage clinical trials.
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South Korea has ordered COVID-19 vaccines for 88 percent of its population, or 44 million people, the government said, announcing deals with four pharmaceutical companies as well as the World Health Organization’s global vaccine project, known as COVAX.
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India must vaccinate 1.3bn people against Covid-19 – twice and twice as fast. With more than 9 million confirmed cases of coronavirus and a battered economy, how will the country meet this challenge?
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Grandmother-of-four Margaret Keenan, 90, has become the first person in the world to receive the shot as part of a vaccination programme.
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China's Sinovac Biotech SVA.O has secured $515 million in funding from a local firm to double production capacity of its coronavirus vaccine, the companies said on Monday, as it expects efficacy data of its experimental shot this month.
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The World Health Organization is holding discussions on Monday about the feasibility of trials in which healthy young volunteers are deliberately infected with coronavirus to hasten vaccine development – amid questions over whether they should go ahead given the promising data from the frontrunner vaccine candidates.
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Indonesia on Sunday received its first shipment of coronavirus vaccine from China, its president announced. "I want to convey the good news that today the government has received 1.2 million doses from China’s Sinovac Biotech Ltd." Joko Widodo told an online news briefing.
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Serum Institute of India, the world's largest vaccine maker by number of doses produced, has sought government approval for emergency use authorisation of the coronavirus vaccine that it is developing with the University of Oxford and British drugmaker AstraZeneca.
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With more than 100 vaccines currently in various trial phases and some reaching the pre-approval stage or being authorized for emergency use, accurate science reporting has never been more important. Journalists play a vital role in informing the public on science, specifically vaccine, developments, in an unprecedented period of scientific
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Britain's Queen Elizabeth II will receive the Pfizer-BioNTech coronavirus vaccine within weeks, after UK regulators granted emergency approval and the world's first roll-out begins next week, reports late Saturday said.
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Recently, AstraZeneca announced its vaccine is about 70 percent effective at preventing COVID-19. But a closer look at the clinical trials shows the efficacy isn’t as clear-cut as the pharmaceutical initially stated. Here’s what experts make of AstraZeneca’s vaccine trials.
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After Wall Street Journal claiming Pfizer and BioNTech suddenly scaled back distribution targets for their mRNA-based coronavirus vaccine in 2020, the drugmaker said those revised plans were nothing new and, in fact, had been laid out last month.
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Western vaccine makers appear to have taken the lead in the global race to produce a vaccine, but Chinese vaccine makers may help fill in the gaps they leave behind.
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In the US, COVID-19 vaccines are just around the corner, leaving the entire country peering out the window in anticipation of their arrival. Officials and healthcare systems, already taxed by skyrocketing case counts are making sure that everything is prepared when they show up
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Moderna will be able to produce 500 million doses of its COVID-19 vaccine in 2021, Chief Executive Officer Stéphane Bancel said on Friday
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China will have 600 million doses of Covid-19 vaccines ready for market this year and will make “a major announcement” soon, a scientist in charge of vaccine development said on Friday.
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Bahrain announced on Friday that it had approved the emergency use of the Pfizer-BioNTech coronavirus vaccine, becoming the second country after Britain to green-light the drug.
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When the pandemic began, rich countries went on a buying spree. Some have even called it "panic buying." These countries started making agreements with pharmaceutical companies to purchase experimental COVID-19 vaccines, even before clinical trials had finished.
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Covid-19 vaccine side-effects that range from fevers and chills to headaches and joint pain could keep some doctors and nurses from working amid a nationwide surge in hospitalizations.
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while people in Europe and the United States can expect the vaccines to become available soon, Chinese drug companies have yet to present their trial data even though the country was among those leading the way in the early phases of the research process.
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Former Presidents Barack Obama, George W. Bush, and Bill Clinton are volunteering to get their COVID-19 vaccines on camera as soon as the US Food and Drug Administration authorizes one for public use.
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Vaccines that prevent symptomatic Covid infection in roughly 95% of people vaccinated should, over time, help the world return to a normal life. But if we’re not careful, we could fail to take full advantage of the opportunity scientists and governments, pharmaceutical companies and philanthropic foundations have created for us.
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The forthcoming vaccines for COVID-19, even though they've been developed in record time, will meet similar standards for safety and effectiveness, according to infectious disease experts, immunologists, and bioethicists who spoke with Mashable.
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Considering worldwide need for a vaccine, there is room for many players. As of Dec. 1, 11 coronavirus vaccine developers have moved their projects into phase 3 clinical trials. Of those 11, five are companies based in the U.S. or Europe. We need all five of these companies -- and
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Russian President Vladimir Putin has ordered mass immunization against COVID-19 as Russia races to reverse a surge in coronavirus cases and be the first in the world to distribute its vaccine widely.
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The UK has approved a COVID-19 vaccine and plans to implement the treatment as early as next week. British care home residents, older adults and health care workers will be first to be inoculated with the groundbreaking vaccine developed by Pfizer and BioNTech to tackle the coronavirus pandemic.
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France hopes to offer Covid-19 vaccinations to the general public between April and June next year, President Emmanuel Macron told a press briefing at the Élysée Palace on Tuesday. Early 2021 will see a first campaign targeting those most at risk followed by a second campaign for the rest of
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Scientists at the University of Pennsylvania and the biotech firm Regeneron are investigating whether technology developed for gene therapy can be used to make a nasal spray that will prevent infection with the new coronavirus.
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Lipid nanoparticles are the fatty molecular envelopes that help strands of mRNA evade the body’s biological gatekeepers and reach their target cell without being degraded. They are enabling some of the most advanced technologies being used in vaccines and drugs.
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The agency, which procures more than 2 billion doses of vaccines annually, will be responsible for supplying Covid-19 vaccines for most low to middle-income Covax members.
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Moderna Inc will apply for US and European emergency authorization for its COVID-19 vaccine on Monday after full results from a late-stage study showed it was 94.1% effective with no serious safety concerns, the company said.
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Serum Institute of India, the world’s largest vaccine producer, sees AstraZeneca Plc’s COVID-19 vaccine candidate as a “very good” option, giving it a major vote of confidence after some experts raised questions around its trial data. Serum Institute CEO sees AstraZeneca's COVID-19 vaccine as 'very good' candidate  Reuters Vaccine giant to
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A Singaporean woman who was pregnant when she was infected with coronavirus in March has reportedly given birth to a baby with antibodies against the disease, offering a new clue as to whether the infection can be transferred from mother to child.
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The problem may just be temporary. Experts say that the vaccine's cold storage requirements may become less stringent as more is learned about how the vaccine reacts to warmer temperatures.
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Global cases have reached 61,585,651, the worldwide death toll has hit 1,441,335. Now Thailand, Malaysia and Philippines have signed deals to secure COVID-19 vaccines.
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AstraZeneca’s will likely conduct another global trial of the effectiveness of its COVID-19 vaccine trial, following the disclosure that the more effective dosage in the existing Phase 3 clinical trial was actually administered by accident.
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Initial data from an US expanded access (EA) use of RLF-100™ (aviptadil) in 90 ICU patients with critical COVID-19 and severe comorbidities point to a 72% survival 28 days after initial treatment.
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While countries around the world anxiously await the arrival of a vaccine for the coronavirus, a growing slice of the Chinese population has reportedly already been vaccinated. In an interview last week with the Sichuan Daily, the chair of the Chinese pharmaceutical company Sinopharm Group said that its Covid-19 vaccines
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Because the different dosing schemes likely led to different immune responses, Hill says researchers have a chance to suss out the mechanism by comparing vaccinated participants’ antibody and T cell levels. The 62% efficacy, he says, “is a blessing in disguise.”
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If regulators approve any of the vaccines in coming weeks, the companies have said distribution could begin almost immediately with governments around the world.
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developers of Russia’s Sputnik V vaccine today reported 91.4% efficacy from a second interim analysis of more than 18,000 people, bolstering a claim the team made on 11 November with scant evidence.
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Indian Prime Minister Narendra Modi warned on Tuesday (Nov 24) that any COVID-19 vaccine could lead to side-effects in some people, as even popular medicines do, and that the government would only go by science in finalising one for the country.
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According to the World Health Organization (WHO), there are more than 150 vaccines under development for COVID-19. Some of the vaccines are getting closer to release as they pass through the third phase of human trials.
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UNICEF is working with more than 350 partners, including major airlines, shipping lines and logistics associations from around the world, to deliver COVID-19 vaccines to over 92 countries, as soon as doses become available, the agency said on Monday.
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The coronavirus vaccine developed by the University of Oxford is highly effective at stopping people developing Covid-19 symptoms, a large trial shows. Interim data suggests 70% protection, but the researchers say the figure may be as high as 90% by tweaking the dose.
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Figuring out what’s needed to achieve herd immunity with COVID-19 vaccines involves a range of factors, several of which are unknown.
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Although antibodies can wane substantially within months—particularly in patients with less severe disease—they sometimes persist, even in mild cases.
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St. Jude Children's Research Hospital scientists have discovered a potential strategy to prevent life-threatening inflammation, lung damage and organ failure in patients with COVID-19.
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Sinovac Biotech's CoronaVac triggered a quick immune response, although the study conducted in April and May this year did not give a percentage of the vaccine's success rate.
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Airlines are now considering options ranging from a large plug-in freezer that can cost about as much as a small car to a multi-layered canister that uses liquid nitrogen to ship vaccines requiring a deep freeze.
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But before any of these jabs have been proven to work, there is another looming roadblock: Some parties, including the United States, European Union and the United Kingdom, are staking their claim to “lion’s share” of doses.
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A crucial step in returning a sense of normalcy after a year ravaged by the coronavirus pandemic, could be hindered by widespread contamination from a range of chemicals used in everyday products.
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Moderna Inc's MRNA.O experimental vaccine is 94.5% effective in preventing COVID-19 based on interim data from a late-stage trial, the company said on Monday, becoming the second U.S. drugmaker to report results that far exceed expectations.
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The final efficacy is likely to be lower, as administering the treatment is difficult for many logistical reasons. In the real world, the vaccine might not be stored at the correct temperature and hence may spoil.
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A new study published in Science confirms that SARS-CoV-2 has mutated in a way that’s enabled it to spread quickly around the world, but the spike mutation may also make the virus more susceptible to a vaccine.
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Pfizer's COVID-19 vaccine this week set high efficacy expectations, but the vaccine has stringent storage needs and requires two doses, creating significant challenges for a global vaccination campaign. Sanofi, J&J and Novavax may be better suited for global distribution.
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Genetic vaccines represent an important step in this scientific evolution. Engineers can now design strands of mRNA on computers, guided by algorithms that predict which combination of genetic letters will yield a viral protein with just the right shape to prod the human body into producing protective antibodies
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Although there is definite reason to be optimistic, experts have cautioned that the data from the trials conducted by Pfizer and BioNTech are not final, and there remain plenty of unknowns.
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The Food and Drug Administration Monday gave the thumbs-up to a drug that's designed to prevent people with mild to moderate COVID-19 from getting sicker.
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Pfizer and BioNTech’s announcement of preliminary efficacy results for their Covid-19 vaccine candidate is a tiny speck of light at the end of a long, dark tunnel. Based on interim data from a late stage clinical trial, their candidate could prevent 90% of Covid-19 infections.
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A vaccine against Covid-19 is in sight, with the announcement of the first interim results in large-scale trials showing the Pfizer/BioNTech candidate is 90% effective, according to the manufacturers.
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An Indian government-backed COVID-19 vaccine could be launched as early as February – months earlier than expected – as last-stage trials begin this month and studies have so far shown it is safe and effective.
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Other developing countries, grappling with spiraling COVID-19 cases, have entered into similar bargains to trial vaccines from China and produce them locally.
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Bahrain has started inoculating frontline workers, who are in direct contact with active Covid-19 cases, with a vaccine. With this, Bahrain becomes the latest country to take the unusual step of granting emergency approval for a shot before finishing safety and efficacy tests.
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Scientists have developed a vaccine candidate for COVID-19 that produces "extremely high levels" of protective antibodies in animal models, an advance that may lead to a novel therapeutic to curb the pandemic.
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Create a cohesive federal plan with consistent messaging, get everyone to wear masks, and implement widespread testing and contact tracing. The countries failing to curb their outbreaks are missing at least one of those elements.
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A coronavirus vaccine under development from CureVac NV showed a good immune response in early trials, validating the biotech company’s 20 years of research into messenger RNA’s ability to train the body’s defenses.
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AstraZeneca Plc said on Sunday Britain’s health regulator had started an accelerated review of its potential coronavirus vaccine. In rolling reviews, regulators are able to see clinical data in real time and have dialogue with drug makers on manufacturing processes and trials to accelerate the approval process.
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Israel began human trials on Sunday for its COVID-19 vaccine candidate which, if successful, could be ready for the general public by the end of next summer.
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A number of candidate vaccines are expected to report results from their final phase trials in the coming weeks and months, and the process is shaping up to be a challenging time for the world’s regulators with multiple vaccines that use different technologies potentially seeking approval.
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MIT research has found that hidden in the sound of coughs is a pattern that subtly, but reliably, marks a person as likely to be in the early stages of infection. It could make for a much-needed early warning system for the virus.
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The ambitious drive to produce Covid-19 vaccine at warp speed seems to be running up against reality. We all probably need to reset our expectations about how quickly we’re going to be able to be vaccinated.
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The first generation of COVID-19 vaccines "is likely to be imperfect" and "might not work for everyone", the chair of the UK Vaccine Taskforce has said.
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Covid-19 vaccine candidates have advanced into final-stage trials faster than any in history, and projections for how many total doses could roll off assembly lines next year now top 16 billion, according to one recent calculation.
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The model found that the initial pandemic peak is largely independent of immunity because most people are susceptible. However, a substantial range of epidemic patterns are possible as SARS-CoV-2 infection—and thus immunity—increases in the population.
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COVID-19 vaccine developers seeking FDA emergency use authorizations won’t have to undergo pre-approval site inspections, FDA agency official Jerry Weir.
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Eli Lilly said Monday that it will end a U.S.-based clinical trial for its coronavirus antibody treatment because the data indicates the treatment is unlikely to help coronavirus patients recover from advanced stages of the disease.
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One of the world's leading Covid-19 experimental vaccines produces an immune response in both young and old adults raising hopes of a path out of the gloom and economic destruction wrought by Covid-19.
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People who have recovered from COVID-19 may worry about lingering health effects, but some may also focus on what they see as the good news: Now they are immune. Or are they?
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Two drugmakers have announced the resumption of US testing of their Covid-19 vaccine candidates. Testing of AstraZeneca’s vaccine candidate had been halted since early September, while Johnson & Johnson’s vaccine study was paused at the beginning of last week.
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The 'curative' power of this antibody treatment has yet to be proven. Although it has shown promise in small, early studies in people with mild COVID-19 symptoms, large clinical trials have not yet been completed. Meanwhile, researchers are already designing more-advanced antibody treatments that could be cheaper, easier to produce
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Two major clinical trials for experimental Covid-19 vaccines got back on track in the United States, providing a glimmer of hope as the number of cases skyrocket across the country.
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U.S. FDA approved the antiviral drug Veklury (remdesivir) for use in adult and pediatric patients 12 years of age and older and weighing at least 40 kilograms (about 88 pounds) for the treatment of COVID-19 requiring hospitalization.
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A participant who died during a trial of AstraZeneca Plc’s Covid-19 vaccine in Brazil hadn’t received the company’s shot, according to a person familiar with the matter. The person asked not to be identified because the information isn’t public.
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A volunteer in AstraZeneca's Covid-19 vaccine trial has died in Brazil, the country's National Health Surveillance Agency said Wednesday.
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The inner bark of the Chilean soapbark tree, Quillaja saponaria, is the source material for some of these saponins. This precious goo does many things well, and it happens to be the raw material for one of the world’s most coveted vaccine adjuvants: QS-21
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Covid-19 is likely to become as “endemic” as the annual flu virus, according to the U.K.’s chief scientific advisor. Some potential vaccines are in late-stage clinical trials, but Patrick Vallance said none is likely to eradicate the virus.
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Monoclonal antibodies for COVID-19 recently took center stage as Regeneron’s experimental cocktail was used to treat President Donald Trump, who went on to rave about it. But that therapy, as is typical for antibody drugs, needs to be injected into the body.
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Over the next few months, the companies behind the leading vaccine candidates will start releasing the first data from large clinical trials. Most likely, they will not be unalloyed good news or bad news. Keeping expectations measured will require understanding when a vaccine clears just one of many hurdles—it doesn’t
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Human challenge trials – in which young, healthy volunteers are intentionally infected with a virus to allow vaccines and treatments to be tested quickly – have been used in the fight against diseases ranging from typhoid and cholera to malaria.
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Even a once bullish PM is now not so optimistic but there are promising signs of a vaccine on the horizon.
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U.S. drug giant Pfizer has started work manufacturing hundreds of thousands of Covid-19 vaccines ahead of an expected U.S. approval in November
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Two Covid-19 vaccines stalled by potential side effects have one key feature in common: Both are based on adenoviruses, cold germs that researchers have used in experimental therapies for decades with varying results.
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Scientists from Britain’s University of Oxford have developed a rapid Covid-19 test able to identify the coronavirus in less than five minutes, researchers said on Thursday, adding it could be used in mass testing at airports and businesses.
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Russia has granted regulatory approval to a second Covid-19 vaccine, according to its register of authorized medicines. A delighted President Vladimir Putin announced the news at a government meeting.
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It’s possible that the spread of an infection will eventually stabilise at a constant level so that it becomes present in communities at all times, possibly at a relatively low, sometimes predictable rate.
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Mexico’s government has made a $159.88m payment to secure access to COVID-19 vaccines through a World Health Organization-backed plan as countries across the globe race to secure supplies.Mexico’s government has made a $159.88m payment to secure access to COVID-19 vaccines through a World Health Organization-backed plan as countries across the
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The study of Johnson & Johnson’s Covid-19 vaccine has been paused due to an unexplained illness in a study participant.
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A tuberculosis (TB) vaccine given to more than 100 million babies each year could help adults fight coronavirus, health experts have said, after trials showed it stimulates the immune system.
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The Covid-19 vaccines closest to the finish line are designed to be injected into the arm. Researchers are looking at whether they can get better protection from inoculations that fight the virus at its point of attack — the nose and mouth.
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China and Indonesia have agreed to work more closely together to fight Covid-19 as Beijing on Friday sought to bolster ties with a regional neighbour through what some analysts are calling “vaccine diplomacy”.
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A Chinese experimental coronavirus vaccine being developed by the Institute of Medical Biology under the Chinese Academy of Medical Sciences was shown to be safe in an early stage clinical trial, researchers said.
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Pharmaceutical companies and research centres around the world are working on COVID-19 vaccines, with large global trials of several of the candidates involving tens of thousands of participants well under way.
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The National Institutes of Health, working in collaboration with the Biomedical Advanced Research and Development Authority (BARDA), today announced a third round of contract awards for scale-up and manufacturing of new COVID-19 testing technologies.
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A vaccine against COVID-19 may be ready by year-end, the head of the World Health Organization said on Tuesday (Oct 6). WHO Director-General Tedros Adhanom Ghebreyesus called for solidarity and political commitment by all leaders to ensure equal distribution of vaccines when they become available.
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China is in talks to have its locally-produced COVID-19 vaccines assessed by the World Health Organization, as a step toward making them available for international use, a WHO official said on Tuesday.
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To quash the virus, the immune system unleashes an arsenal of powerful weapons. Sometimes these turn inward and destroy healthy tissues. Combatting this friendly fire has become as crucial a part of the Covid-19 treatment strategy as subduing the virus itself.
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With the world again facing a deadly infectious disease, the willingness of the US and China to put aside their differences and work together to solve this century’s biggest public health crisis remains in question.
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Might common colds explain a great deal of preexisting immunity, and if so, could the responsible virus help save lives during the current pandemic?
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Post Covid-19 vaccine candidates are being tested on people of all ages. Photo: APCovid-19 vaccine candidates are being tested on people of all ages. Photo: AP Covid-19 vaccine candidates are being tested on people of all ages. Photo: AP While the world waits to find out if any of the
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Oxford Coronavirus (COVID-19) Vaccine Update: The newspaper quoted UK government sources involved in the making and distribution of vaccines as saying that a full vaccine roll-out programme for adults could take six months or less after approval.
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Even an effective coronavirus vaccine will not return life to normal in spring, a group of leading scientists has warned. We need to be "realistic" about what a vaccine could achieve and when.
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A successful vaccine for Covid-19 will not conquer the spread of the virus alone, with restrictions on daily life likely to continue for some time, a team of experts have said.
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Billions of dollars’ worth of coronavirus vaccine contracts have avoided usual mechanisms of transparency and regulatory oversight with Operation Warp Speed - the Trump administration’s project to develop a Covid-19 vaccine - which is funneling money through a nongovernmental intermediary.
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A test that can diagnose Covid-19 in minutes will dramatically expand the capacity to detect cases in low- and middle-income countries, the World Health Organization (WHO) has said. The $5 (£3.80) test could transform tracking of Covid-19 in less wealthy countries, which have shortages of healthcare workers and laboratories.
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In the race to develop a vaccine for the coronavirus, one deadline has been defined with a precision that, if not scientific, has the clarity of an equation: the first Tuesday in November. Throughout the fall, Donald Trump has frequently intimated that a vaccine might be approved before the election.
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Regeneron said Tuesday that its experimental two-antibody cocktail reduced viral levels and improved symptoms in non-hospitalized patients with mild-to-moderate Covid-19.
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Serum Institute of India will make up to 200 million COVID-19 vaccine doses for poorer countries, including India, next year, as the Bill & Melinda Gates Foundation and GAVI vaccines alliance have doubled their funding.
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Older people are being excluded from the vast majority of trials to find treatments and a vaccine for COVID-19, according to a study. Around 9% of the global population is 65 and older, but this demographic has accounted for up to 40% of coronavirus cases and 80% of deaths.
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China's indications that mass production of vaccines is imminent has raised questions about capacity, efficacy and availability. Out of 300 vaccine candidates around the world, nine are in phase 3 human trials, according to WHO. Four of those are being produced in China.
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A Manchester man has become the first UK patient to be given an experimental arthritis drug in a clinical trial to treat severe Covid-19. He has received a dose of otilimab – in hopes that this drug could also ease the effects of Covid-19.
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Half a million sharks could be killed for their natural oil to produce coronavirus vaccines, according to conservationists. One ingredient used in some COVID-19 vaccine candidates is squalene, a natural oil made in the liver of sharks.
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India’s ability to develop and distribute a Covid-19 vaccine will be used to help the world, said Prime Minister Narendra Modi. “As the largest vaccine-producing country in the world, today I would like to give one more assurance to the global community,” Modi said Saturday in a pre-recorded video statement
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The world still lacks a proven coronavirus vaccine, but that has not stopped Chinese officials from trying to inoculate tens of thousands, if not hundreds of thousands, of people anyway. Three vaccine candidates are being injected into workers whom the government considers essential, along with many others.
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Several ongoing coronavirus-vaccine trials could announce game-changing results next month. But as anticipation grows, concerns are growing about whether the vaccines will clear safety trials, what they will achieve if they do and the risk that the approval process will be influenced by politics, or at least seem to be.
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A single dose of Johnson & Johnson's JNJ.N experimental COVID-19 vaccine produced a strong immune response against the novel coronavirus in an early-to-mid stage clinical trial, according to interim results published on Friday.
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A mix of ultrapotent antibodies from recovered COVID-19 patients has been shown to recognize and lock down the infection machinery of the pandemic coronavirus and keep it from entering cells. Each of the antibody types performs these overlapping tasks in a slightly different way.
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South Korea appears to have cracked the code for managing the coronavirus. Its solution is straightforward, flexible and relatively easy to replicate.
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The poor and weakest members of society should get preferential treatment when a vaccine for the coronavirus is ready, Pope Francis told the United Nations on Friday (Sep 25).
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Hospitalized COVID patients who were vitamin D sufficient had a significant decreased risk for adverse clinical outcomes including becoming unconscious, hypoxia (body starved for oxygen) and death.
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The vaccine maker Novavax said Thursday that it would begin the final stages of testing its coronavirus vaccine in the United Kingdom and that another large trial was scheduled to begin next month in the United States.
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A fifth of people are likely to refuse a Covid vaccine when one becomes available, according to the largest survey of UK attitudes and behaviour during the pandemic.
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Healthy volunteers in the UK could soon be deliberately infected with coronavirus in the world’s first human challenge trial to find out which Covid vaccines work.
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Higher levels of zinc in the blood were tied to lower levels of pro-inflammatory proteins when patients were infected, the Spanish researchers said. Every unit increase of zinc in the blood was tied to a 7% lowering of the odds that a patient would die while in the hospital.
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Johnson & Johnson JNJ.N on Wednesday began a 60,000-person trial of an experimental single-shot COVID-19 vaccine that, if proven effective, could simplify distribution of millions of doses compared with leading rivals requiring two doses.
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One clinical trial of monoclonal antibodies — human-made versions of immune system defenders produced by the body — suggests that the drugs can help keep people hospitalized with COVID-19 from needing a ventilator or from dying.
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The Covid-19 vaccine trial designed by Pfizer Inc. and its German partner BioNTech SE may allow them to find whether their shot works before their fastest-moving rivals. The companies plan a first look after a mere 32 coronavirus infections have accumulated in their massive 44,000-person trial.
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Some researchers conducting clinical trials on a COVID-19 vaccine have not revealed to the public what the placebo contains, but they should. This is because the placebo ingredients influence how effective or harmful the active treatment, with which the placebo is compared, appears.
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When can I get a vaccine? When can my kids get it? It may come as a surprise that the answers are not the same. Adults may be able to get a vaccine by next summer. But their kids will have to wait longer. Perhaps a lot longer.
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RIO DE JANEIRO (Reuters) - A new study that analyzed the coronavirus outbreak in Brazil has found a link between the spread of the virus and past outbreaks of dengue fever that suggests exposure to the mosquito-transmitted illness may provide some level of immunity against COVID-19.
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The health ministry could give the go-ahead this year, making Avigan the third drug overall and the first domestically developed drug to receive such approval. Japan previously approved dexamethasone and remdesivir as coronavirus treatments.
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Experts are concerned that the company has not been more forthcoming about two participants who became seriously ill after getting its experimental vaccine.
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THINK ABOUT A vaccine against Covid-19 like the venerable winter sport of curling. The giant granite stone sliding along the ice (the “sheet”) inexorably toward a target (the “house”) is President Donald Trump, sunny optimist, touting a vaccine “sometime in October.” That’s only two weeks away!
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At the facility, a sterile production line could be mass producing a vaccine within weeks. Right now, they're training staff by filling glass vials with water. They could start filling vials with a vaccine as early as November, maybe even before a vaccine has been approved.
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The growing calls for transparency have led Moderna (PDF), swiftly followed by Pfizer/BioNTech (and a pledge from AstraZeneca), to release their protocols this week, all of which are in the later stages of testing and likely to see data, and maybe emergency approvals, in the coming months.
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The coronavirus pandemic is taking a turn for the worse in Southeast Asia. As total COVID-19 cases pass 30 million, and the world closes in on its millionth death from the contagion, a region once viewed as a success story is seeing persistent and accelerating infections in several nations.
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More than 941,300 people have died from COVID-19, the disease caused by the new coronavirus, while over 29.8 million infections have been confirmed in at least 188 countries and territories. More than 20.8 million people have recovered to date.
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Jennifer Doudna, one of the pioneers of the gene-editing technique known as CRISPR, thinks the biotech tool could be an essential one for combating COVID-19 and future pandemics. Due to its capacity to be “reprogrammed” like software, CRISPR could eventually be integral to countless tests and treatments.
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The biotech company Moderna released a 135-page document on Thursday that spells out the details of how it is conducting the late-stage trial of its coronavirus vaccine, and how safety and efficacy will be determined.
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My wife and I are participating in a clinical trial for a Covid-19 vaccine. We had no antibodies before we received the vaccine, but we now have a lot of them, according to two independent tests. Presumably we are like millions of others who have recovered from Covid-19.
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Global delays in finding a working vaccine would be devastating to nations that have bet heavily on one. Indonesia, for instance, has a large informal workforce that risks starvation during lockdowns.
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President Donald Trump again raised hopes -- and concern -- about swift U.S. approval for a coronavirus vaccine, saying at a town hall event hosted by ABC News that the shot could be ready within four weeks.
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A new review published in Frontiers in Public Health suggests that COVID-19, the illness caused by the SARS-CoV-2 virus, will likely become seasonal in countries with temperate climates, but only when herd immunity is attained.
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The United Arab Emirates has become the first country outside China to approve emergency usage of a Chinese Covid-19 vaccine candidate, in a vote of confidence for a state-backed drugmaker racing global rivals to stop the spread of the coronavirus.
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Coronavirus vaccines being developed in China may be ready for use by the general public as early as November, an official with the China Centre for Disease Control and Prevention (CDC) said.
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UK researchers are to begin trials of inhaled coronavirus vaccines.
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The Oxford-based Recovery trial which proved that steroids saved the lives of some Covid patients will now take on a promising but far more expensive new antibody combination treatment, it has been announced.
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AstraZeneca (AZN) has resumed its Phase 3 vaccine trial in the U.K., marking the end to a brief but abrupt interruption to the global frontrunner in the vaccine race.
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NEW DELHI: In a stunning revelation, a Chinese virologist has claimed that the coronavirus was created in a government-controlled laboratory in Wuhan, the original epicentre of the outbreak and offered scientific evidence to back her claims.
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With pledges of a coronavirus vaccine, China is on a charm offensive to repair strained diplomatic ties and bolster engagement with other countries.
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Dampening hopes of a Covid-19 vaccine by year-end, the chief executive of the world’s largest manufacturer of vaccines has said that adequate coronavirus vaccine will not be available for everybody in the world to be immunised until the end of 2024. In an interview with the Financial Times, Adar Poonawalla,
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People in high-risk groups encouraged to get an influenza jab to help ease pressure on the country’s health system But efforts are hampered by cost, lack of access and public concerns about quality
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Within the next week, Pfizer (NYSE:PFE) and BioNTech (NASDAQ:BNTX) expect to reach their goal of enrolling 30,000 participants in the phase 2/3 clinical trial testing their coronavirus vaccine, BNT162b2.
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The chief executive of Phizer Inc. said Sunday that the pharmaceutical giant should know if its experimental COVID-19 vaccine works by the end of October — and if approved, it could be distributed in the U.S. by the end of the year.
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Researchers say drug companies need to be more open about how vaccine trials are run to reassure Americans who are skittish about getting a coronavirus vaccine.
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The company said tests of its vaccine would start up again in Britain while remaining suspended in the U.S. and other countries. Pfizer, a competitor, announced an expansion of its trials.
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Drugmaker AstraZeneca announced Saturday that its COVID-19 vaccine studies have resumed in the United Kingdom, though not yet in the United States. The vaccine trials had been placed on hold around the world earlier in the week after a U.K. participant in one of the studies developed a neurological illness.
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White House and Republican officials struggled to respond to sharp questioning by Sunday morning news show hosts about why President Trump knowingly played down the coronavirus in the crucial early months of the pandemic, as revealed by the journalist Bob Woodward in his new book, “Rage.”
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Here are five things you need to know about the coronavirus pandemic on Sunday. We'll have another update for you on Monday morning.
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Trials of a Covid-19 vaccine being developed by AstraZeneca and Oxford University will resume after being paused due to a reported side effect in a patient in the UK.
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PARIS - Clinical trials of one of the most advanced experimental COVID-19 vaccines resumed Saturday after a brief safety pause, as infection numbers continued to march upward in countries across the globe.
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Vaccines are making progress, but they may not defeat the virus completely. Luckily, other therapies are on the way, too.
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This Saturday, July 18, 2020 file photo shows a general view of AstraZeneca offices and the corporate logo in Cambridge, England. Late stage trials into a coronavirus vaccine developed by Oxford University and drugmaker AstraZeneca were paused after a woman who received the experimental shot developed severe neurological symptoms, a
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As we get closer to a COVID-19 vaccine, it's exciting to imagine a day when the virus is gone. But a vaccine will not be a magic bullet. In fact, it may be only about 50% effective.
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New details of how the president has demanded faster action from health agencies help explain the intensifying concern that he could demand pre-Election Day approval of a vaccine.
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As government and private money pour into the global race for a Covid-19 vaccine, drugmakers are under great pressure to keep the shot affordable while also keeping investors happy. WSJ explains what this means for the final price tag of the jabs.
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As optimism on Wall Street grows about potential FDA approval for a coronavirus vaccine, here are six stocks that could make outsized gains and rebound on the news, according to experts from Stifel.
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AstraZeneca’s vaccine trials resume in Britain after a safety review. Michigan State University students are asked to quarantine after an uptick in cases.
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President Rodrigo Duterte's pardon of a United States (US) marine convicted of killing a transgender woman should help the Philippines gain access to coronavirus vaccines being developed by American companies, his spokesman said Thursday.
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New cases of coronavirus are doubling almost weekly across England, figures revealed, as Birmingham became the biggest local authority to announce a tightening of lockdown measures and health officials flagged “worrying signs” of infections in elderly people.
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The UK has ordered a total of 340m doses of potential coronavirus vaccines from six manufacturers. The EU has done a deal said to be worth €2.4bn (£2.2bn) with one developer, while the US has orders with six companies for 800m doses under Operation Warp Speed, with options on a
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The newest Covid-19 vaccine candidate to start human testing is the first where volunteers won’t get a painful injection. Instead, they’ll receive a spray through the nose.
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If or when scientists succeed in making a coronavirus vaccine, there won't be enough to go around. Research labs and pharmaceutical companies are rewriting the rulebook on the time it takes to develop, test and manufacture an effective vaccine.
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The global race is on for a vaccine to combat the coronavirus, but the question is: Who will be included? To date, several companies have reached Phase 3 trials for an experimental vaccine — including Moderna, Pfizer, AstraZeneca and CanSino. AstraZeneca recently announced a pause in its process to check
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China has taken a shortcut in the global sprint to develop and deliver vaccines for the novel coronavirus. Sinopharm, the state-owned company developing two of China’s leading vaccine candidates, told China National Radio on Monday that it has already vaccinated hundreds of thousands of Chinese citizens — even though the
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Verdict: A database of worldwide shipments of chemical supplies created in 2020, but going back to 2015, did refer to their use for "Covid-19 kits". The World Bank, one of the international organisations responsible for maintaining the list, says this was because these previously existing products are now being used
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George Washington University invited me to participate in Moderna’s vaccine trial because I am triple-risk: a Black woman, a Type 1 diabetic and asthmatic.
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Here’s what you need to know about the impact of Covid-19 to navigate the markets today.
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By: Explained Desk | New Delhi | Updated: September 5, 2020 7:53:50 am Obesity can make it more difficult to fight a Covid-19 infection, according to a manuscript published in Endocrinology, the journal of the international medical organisation Endocrine Society. (Photo: Reuters) Obesity can make it more difficult to fight
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The World Health Organization said Friday, September 4, it did not expect widespread immunization against the novel coronavirus until mid-2021, despite growing expectations in the US and beyond that a vaccine could be released within weeks. Across the world, governments are hoping to announce a vaccine as soon as possible and roll
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Related TopicsCoronavirus pandemic image copyrightReuters Russian scientists have published the first report on their coronavirus vaccine, saying early tests showed signs of an immune response. The report published by medical journal The Lancet said every participant developed antibodies to fight the virus and had no serious side effects. Russia licensed
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LONDON - Patients involved in early tests of a Russian coronavirus vaccine developed antibodies with "no serious adverse events", according to research published in The Lancet Friday, but experts said the trials were too small to prove safety and effectiveness. Russia announced last month that its vaccine, named "Sputnik V"
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TipRanks Billionaire Ken Griffin Snaps Up These 3 “Strong Buy” Stocks As fears of a tech bubble and stretched valuations become the talk of the town, investors are turning to Wall Street titans for guidance, namely Ken Griffin. Founding hedge fund Citadel in 1990, the firm now boasts over $35
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September 4, 2020 at 8:16 AM EDT Senate GOP struggles to unify behind coronavirus relief bill amid dispute over DeVos education policy A fight over Education Secretary Betsy DeVos’s plan to subsidize private school tuition is threatening to derail a Senate GOP effort to write a slimmed-down coronavirus relief bill,
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Speaking from the Oval Office, President Trump praised vaccine development efforts and his administration's response to Covid-19. The President told reporters he thinks the public will hear some "very good news" on vaccines. Trump said he's spoken to the chief of drug-maker Pfizer as the company claims it's on track
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In a call to Governments everywhere to take greater steps to tackle non-communicable diseases (NCDs), the World Health Organization (WHO) said that the pandemic has exposed the fact too little has been achieved, even though these illnesses account for seven in 10 deaths worldwide. WHO Director General Tedros Adhanom Ghebreyesus,
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NATURE BRIEFING 04 September 2020 There are 321 confirmed COVID-19 vaccine candidates, 32 of which have already entered clinical trials. Plus, India’s vaccine production paradox and when Wolfgang Pauli met Carl Jung. Flora Graham Search for this author in: Hello Nature readers, would you like to get this Briefing in
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The vaccine by Cambridge, Massachusetts-based Moderna Inc., generated antibodies similar to those seen in people who have recovered from COVID-19 in a study volunteers who were given either a low or medium dose. Ted S. Warren | AP Most Americans likely won't get immunized with a coronavirus vaccine until the
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With COVID-19 vaccine hype intensifying each day—including this week, with new comments from Pfizer’s CEO—the head of the U.S. government’s research program said it's "extremely unlikely" a vaccine will be available in early November. Moncef Slaoui, the Operation Warp Speed head, told NPR it remains “extremely unlikely, but not impossible" a vaccine will be
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Moderna, one of the developers in the lead for a vaccine to prevent Covid-19, is slowing enrollment slightly in its large clinical trial to ensure it has sufficient representation of minorities most at risk for the disease, its chief executive said. The trial is designed to enroll 30,000 people in
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Coronavirus tests: which one should you take? New coronavirus tests are being developed every day. The Trump administration just ordered 150 million rapid antigen tests from Abbott Laboratories, but how do they stack up against other tests like the Polymerase chain reaction (PCR) test? Top infectious disease doctors from Harvard
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Russia drew criticism when it announced the world's first approved coronavirus vaccine for public use in August -- even before crucial Phase 3 trials had been completed. In the Phase 1 and 2 studies of the vaccine, which is named Sputnik V, all 76 study participants developed antibodies to the
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Need to see how truly protective the vaccine is and how safe it is, the WHO says. (Representational) Geneva: The World Health Organization does not expect widespread vaccinations against COVID-19 until the middle of next year, a spokeswoman said on Friday, stressing the importance of rigorous checks on their effectiveness
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Deciding who should get the vaccine first is not an easy question. By Dr. Dave Harrison September 4, 2020, 9:01 AM • 6 min read Share to FacebookShare to TwitterEmail this article With potential authorization for a COVID-19 vaccine by the Food and Drug Administration within striking distance, scientists and
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Health and Human Services (HHS) Secretary Alex Azar said it’s “irresponsible” to suggest politics are at play in the race to approve a coronavirus vaccine. During an appearance Thursday on CBS, anchor Tony Dokoupil said that “people are worried politics is leading” after the Centers for Disease Control (CDC) issued
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In the race to develop a COVID-19 vaccine, a lot of attention has been paid to the types of vaccines being developed and their progress through the various stages of clinical trial. A lot less attention has been paid to what happens after a vaccine is approved by the regulators.
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A handful of the dozens of experimental COVID-19 vaccines in human testing have reached the last and biggest hurdle: looking for the needed proof that they work as a U.S. advisory panel suggested Tuesday a way to ration the first limited doses once a vaccine wins approval. AstraZeneca announced Monday its vaccine
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This is bananas. US researchers working frantically to test potential COVID-19 vaccines are facing a critical shortage of one essential resource — monkeys. “Nationally, there is basically a big shortage,” Koen Van Rompay, an infectious-disease scientist at the California National Primate Research Center, told The Atlantic. DIETS HIGHER IN PROTEIN, PARTICULARLY PLANT PROTEIN,
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Convalescent plasma from a recovered coronavirus disease (COVID-19) patient is seen at the Central Seattle Donor Center of Bloodworks Northwest during the outbreak in Seattle, Washington, April 17, 2020. Lindsey Wasson | Reuters A panel of experts convened by the National Institutes of Health said Tuesday there is "insufficient data"
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The head of the U.S. Food and Drug Administration (FDA) said on Sunday that he is willing to fast-track a coronavirus vaccine in an effort to make it available as soon as possible. Speaking to the Financial Times, Commissioner Stephen Hahn said the FDA is willing to authorize a vaccine
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White House coronavirus task force coordinator Dr. Deborah Birx on Sunday said that while she’s “hopeful” for a  vaccine, she’s also convinced that the spread of COVID-19 can be stopped through mask-wearing and social distancing. Speaking at an event in Minnesota, Birx urged Americans to “do the right thing” now,
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172 economies are now engaged in discussions to potentially participate in COVAX, a global initiative aimed at working with vaccine manufacturers to provide countries worldwide equitable access to safe and effective vaccines,
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